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Dr. Douglas Matthews is a biological psychologist that is interested in the relationship between brain function and behavior. Specifically he studies: 1. The effect of the hippocampal formation on learning and memory and 2. The effect of drugs of abuse, specifically alcohol, on brain function. His research is multi-level and spans mouse genetics, single cell electrophysiology, molecular biology, animal behavior and human behavior. His research has been awarded over $2.0 million from the United States government and has been covered by several popular press sources. Dr. Matthews serves on the Editorial Board for the Journal Alcohol.
Education
1999 - Post Doctoral Research Fellow, University of North Carolina-Center for Alcohol Studies
1996 - Post Doctoral Research Associate, Miami University
1996 - Ph.D. in Psychology, Miami University
1994 - M.A. in Psychology, Miami University
1991 - B.S. in Psychology/Biology (cum laude), Southwest Missouri State University
Research Interests
- Neurobiological changes due to alcohol abuse
- Effects of acute ethanol exposure on brain function
- Impact of hippocampal function on learning and memory
SELECTED PUBLICATIONS
Tokunaga, S., Silvers, J. & Matthews, D.B. (2006). Chronic intermittent ethanol exposure during adolescence blocks ethanol-induced inhibition of spontaneously active hippocampal pyramidal neurons. Alcoholism: Clinical and Experimental Research, 30, 1-6.
Goldowitz, D., Matthews, D.B., Hamre, K.M., Mittleman, G., Chesler, E.J., Becker H. C., Lopez, M.F., Jones, S.R., Mathews, T.A., Miles, M.F., Kerns, R. & Grant, K.A. (2006). Progress in using mouse inbred strains, consomics and mutants to identify genes related to stress, anxiety and alcohol phenotypes. Alcoholism: Clinical and Experimental Research, 30, 1066-1078.
Werner, D.F., Blednov, Y.A., Ariwodola, O.J., Silberman, Y., Logan, E., Berry, R.B., Borghese, C., Matthews, D.B., Weiner, J.L., Harrison, N.L., Harris, R.A., Homanics, G.E. (2006). Knock-in mice with ethanol-insensitive alpha1-containing GABAA receptors display selective alterations in behavioral responses to ethanol, Journal of Pharmacology and Experimental Therapeutics, 319, 219-227.
Silvers, J.M., Tokunaga, S., Mittleman, G., O’Buckley, T., Morrow, A.L. & Matthews, D.B. (2006). Chronicintermittent ethanol exposure during adolescence reduces the effect of ethanol challenge on hippocampal allopregnanolone levels and Morris water maze task performance, Alcohol, 151-158.
Hamre, K.M, Wilkenson, S., Goldowitz, D.G. & Matthews, D.B. (2007). Screening for ENU-Induced mutations in mice that result in aberrant ethanol-related phenotype. Behavioral Neuroscience, 121, 665-678.
Goa, J., Maison, S.F., Wu, X., Hirose, K., Jones, S.M., Bayazitov, I., Tian, Y., Mittleman, G., Matthews D.B., Zakharenko, S., Liberman, M.C. & Zuo, J. (2007). The orphan glutamate receptor [d]1 subunit is required for high-frequency hearing. Molecular Cellular Biology, 27, 4500-4512.
Matthews, D.B., Morrow, A.L., O’Buckley, T., Berry, R.B., Mittleman, G., Goldowitz, D., Tokunaga, S. & Silvers, J.M. (2008). The effect of acute mild footshock on ethanol self-administration and plasma corticosterone levels in three commonly used mouse strains. Alcohol, 42, 469-476.
Matthews, D.B., Chesler, E.J., Cook, M.N, Cockroft, J., Philip, V.M. & Goldowitz, D (2008). Genetic mapping of vocalization to a series of increasing acute footshocks using B6.A consomic and B6.D2 congenic mouse strains. Behavior Genetics, 38, 417-423. Awarded Fulker Award from Behavior Genetics Association.
Berry, R.B., Werner, D.E., Wang, X., Mittleman, G., Jablonski M.M., Homanics, G.E. & Matthews, D.B. (2008). Mice with Targeted Genetic Reduction of GABAA Receptor a1 Subunits Display Performance Differences in Morris Water Maze Tasks. Neurobiology of Learning and Memory, 90, 580-583.
Matthews, D.B., Tinsley, K., Diaz-Granados, J.L., Tokunaga, S. and Silvers, J.M. (2008). Chronic intermittent exposure to ethanol during adolescence produces tolerance to the hypnotic effects of ethanol in male rats: a dose dependent analysis. Alcohol, 42, 617-621.
Berry, R.B., Chandra, D., Diaz-Granados, J.E., Homanics, G.E. & Matthews, D.B. (2009). Investigation of ethanol-induced impairment of spatial memory in γ2 heterozygous knockout mice. Neuroscience Letters, 455, 84-87.
Kumar, S., Porcu, P., Werner, D.F., Matthews, D.B., Diaz-Granados, J.L., Helfand, R.S., & Morrow, A.L. (in press). The Role of GABAA Receptors in the Acute and Chronic Effects of Ethanol: A Decade of Progress. Psychopharmacology.
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