Annabel Chen Shen-Hsing

Annabel Chen Shen-Hsing

Associate Professor



Email: AnnabelChen@ntu.edu.sg
Office: HSS-04-19
Phone No: 63168836

Annabel Chen is a clinical neuropsychologist (licensed in Clinical Psychology, USA; Singapore Registry of Psychologists) and has worked with both adult and child populations. After completing her clinical psychology internship at West Virginia University School of Medicine, she went on to pursue a post-doctoral clinical residency in adult clinical neuropsychology at the Medical College of Wisconsin. She subsequently worked as a post-doctoral research affiliate at the Lucas MRS/I Center at Stanford University School of Medicine, and was an assistant professor at the National Taiwan University before joining Nanyang Technological University. She has a diverse research background, including animal drug studies, human neuropsychological research and cognitive rehabilitation. She has employed Positron Emission Tomography (PET) to study patients with post-concussion sequelae from mild traumatic brain injury, and has been involved in functional Magnetic Resonance Imaging (fMRI) research examining language processing, executive functions, and affective memory in healthy and clinical populations (e.g. stroke, anxiety, schizophrenia), as well as, assessing neural systems used in motor timing/timing perception in patients with Parkinson's Disease. She has also employed fMRI-guided Transcranial Magnetic Stimulation (TMS) to study higher cognition in the cerebellum.

Education

Ph.D. & M.S., Clinical Rehabilitation Psychology, Purdue University, Indianapolis, Indiana (APA accredited)

B.A., Psychology (Honors), National University of Singapore

Research Interests
  • She is the director of the Clinical Brain Lab, which employs neuropsychological and neuroimaging techniques, such as, fMRI, diffusion MRI and Transcranial Magnetic Stimulation (TMS) to investigate neural substrates possibly involved with higher cognition in the cerebellum.
  • The goal of this research is to apply these paradigms to study the cerebro-cerebellar circuitry in clinical populations, such as mild head injury, dyslexia, autism, and alcoholism.
  • She is also developing research in normative studies and tasks standardization in clinical fMRI, and has interests with ethical and clinical issues involved with neuroimaging for clinical applications and research.

SELECTED PUBLICATIONS

Kirschen MP, Chen SHA, Desmond JE (In Press) Modality Specific Cerebro-Cerebellar Activations in Verbal Working Memory: An fMRI Study. Behavioral Neurology.

Chen SH A, Matsuo K, Nakai T, Bagarinao E, Ho M-H R, Tseng W-Y I, Hue C-W (2009) Reproducibility analysis to validate language processes in Kanji and Chinese characters under different scanner environments. Medical Imaging Technology, 27(4), 217-223.

Nakai T, Bagarinao E, Miyakoshi M, Matsuo K, Tseng WYI, and Chen SHA (2009) Medical GRID as an ICT for Collaborative Neuroimaging, IEICE Technical Report MI2008-132U, 329 – 334.

Kirschen MP, Davis-Ratner MS, Milner MW, Chen SHA, Schraedley-Desmond P, Fisher PG and Desmond JE (2008) Verbal memory impairments in children after cerebellar tumor resection. Behavioural Neurology, 20, 1-15.

Chen S-HA, Tseng W-Y, Nakai T, Bagarinao E, Matsuo K. (2008) A Vision for Translating Neuroimaging Techniques into Clinical Applications through Collaboration. Brain Imaging and Behavior, 2(4):350-8.

Schulte T, Chen SHA,  Muller-Oehring EM, Adalsteinsoon E, & Pfefferbaum A (2006) fMRI Evidence for individual differences in premotor modulation of extrastriatal visual-perceptual processing of redundant targets. NeuroImage, 30(3), 973-982.

Desmond JE, Chen SHA, & Shieh PB (2005) Right cerebellar transcranial magnetic stimulation (TMS) impairs verbal working memory performance. Annals of Neurology, 58, 553-560.

Chen SHA., & Desmond JE (2005).  Temporal Dynamics of Cerebro-Cerebellar Network Recruitment During a Cognitive Task. Neuropsychologia, 43(9), 1227-1237

Chen SHA., & Desmond JE (2005). Cerebro-cerebellar networks during articulatory rehearsal and verbal working memory tasks. NeuroImage, 24(2), 332-338.

Kirschen MP, Chen SHA, Schraedley-Desmond P, & Desmond JE (2005). Load and practice dependent increases in cerebro-cerebellar activation in verbal working memory: An fMRI study. NeuroImage, 24(2), 462-472.

Desmond JE, Chen SHA, DeRosa E, Pryor MR, Pfefferbaum A, & Sullivan EV. (2003). Increased Fronto-Cerebellar Activation in Alcoholics During Verbal Working Memory: an fMRI Study. NeuroImage, 19(4), 1510-20.

Sullivan EV, Harding AJ, Pentney R, Dlugos C, Martin PR, Parks MH, Desmond JE, Chen  SHA, Pryor MR, De Rosa E, Pfefferbaum A (2003). Disruption of frontocerebellar circuitry and function in alcoholism. Alcoholism-Clinical and Experimental Research, 27, 2, 301-309.

Chen SHA, Kareken DA, Fastenau PS, Trexler LE, & Hutchins GD. (2003). A study of persistent post concussion symptoms in mild head trauma using positron emission tomography. Journal of Neurology, Neurosurgery, and Psychiatry, 74, 326-332. (Editor’s Choice)

Desmond JE & Chen SHA. (2002). Ethical issues in the clinical application of fMRI: factors affecting the validity and interpretation of activations. Brain and Cognition, 50, 482-497